منابع مشابه
Biosynthesis of presqualene pyrophosphate by liver microsomes.
Microsomes from rat liver have been shown to synthesize a squalene precursor from farnesyl pyrophosphate. This intermediate is identical with presqualene pyrophosphate, a 30-carbon cyclopropane containing pyrophosphate ester that had previously been isolated from yeast. The squalene precursor was found to be tightly, but not covalently, bound to microsomes.
متن کاملSolubilization and Purification of tram-Farnesyl
A trans-farnesyl pyrophosphate-squalene synthetase has been isolated in a soluble form from yeast extracts and purified 45fold. The molecular weight of the enzyme estimated from sucrose density gradient centrifugation and gel filtration chromatography is 426,000. Solubilization of the squalene synthetase is achieved with deoxycholate. Treatment with the detergent markedly lowers squalene synthe...
متن کاملUridine - 5 ’ - Pyrophosphate Derivatives
The first evidence for the existence of uridine diphosphate compounds was limited to the observation that Staphylococcus aureus cells, when grown in the presence of penicillin, accumulated a new form of acid-labile phosphate in their internal environment (1). The labile phosphate appeared to be part of a complex compound which also contained uracil. In a brief note (2), it has since been report...
متن کاملHepatic phosphoribosyl pyrophosphate concentration
Measurements have been made of the tissue content of phosphoribosyl pyrophosphate (PPRibP) and of a range of metabolic intermediates involved in the energy charge of the cell, the glycolytic and pentose phosphate pathways, and of the activity of the enzymes of the pentose phosphate pathway and of PPRibP synthetase (EC 2.7.6.1) in the livers of normal, diabetic, insulin-treated diabetic and star...
متن کاملPyrophosphate arthropathy in hypophosphatasia.
The association of hypophosphatasia and pyrophosphate arthropathy in an adult patient has been described on 1 previous occasion. We report a further 2 patients with this disease combination. One patient suffers from the type of hypophosphatasia that presents in adult life, with fractures that are either spontaneous or the result of minimal trauma. The other patient suffered from the severe type...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1974
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)42536-2